2480283-93-8

2480283-93-8 structure

Name: hCAI/II-IN-3
Chemical Name: hCAI/II-IN-3
CAS Number: 2480283-93-8
Molecular Formula: C₁₆H₁₈N₄O₄S₂
Molecular Weight: 394.47
Catalog: Signaling Pathways Metabolic Enzyme/Protease Carbonic Anhydrase
Create Date: 2022-08-17 10:50:59
Modify Date: 2024-01-13 11:05:04
hCAI/II-IN-3 (compound 5b) is a potent dual hCA I/II inhibitor with Ki values of 51.25, 13.15 and 42.18 nM for hCA I, hCA II and hCA Ⅸ. hCAI/II-IN-3 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity[1].

Name	hCAI/II-IN-3

Description	hCAI/II-IN-3 (compound 5b) is a potent dual hCA I/II inhibitor with Ki values of 51.25, 13.15 and 42.18 nM for hCA I, hCA II and hCA Ⅸ. hCAI/II-IN-3 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase
In Vitro	hCAI/II-IN-3 (compound 5b) (5-200 μM, 48 hours; HEK293T cells) has no obvious toxicity at HEK293T cells[1]. Cell Cytotoxicity Assay[1] Cell Line: Embryonic kidney (HEK293T) cells Concentration: 5, 25, 50, 100 and 200 μM Incubation Time: 48 hours Result: Had no apparent cytotoxicity.
References	[1]. Yang C, et al. N-Quinary heterocycle-4-sulphamoylbenzamides exert anti-hypoxic effects as dual inhibitors of carbonic anhydrases I/II. Bioorg Chem. 2020 Jul;100:103931.

Molecular Formula	C₁₆H₁₈N₄O₄S₂
Molecular Weight	394.47