2417022-19-4

2417022-19-4 structure

Name: Enpp-1-IN-13
Chemical Name: Enpp-1-IN-13
CAS Number: 2417022-19-4
Molecular Formula: C₂₈H₂₂ClN₅OS
Molecular Weight: 512.03
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2022-08-15 13:27:28
Modify Date: 2024-01-18 20:57:38
Enpp-1-IN-13 (Compound 1a) is an ectonucleotide pyrophosphatase/phosphodiesterase (ENPP) inhibitor with IC50 values of 1.29 μM and 20.2 μM against ENPP1 and ENPP3, respectively. Enpp-1-IN-13 shows anticancer activity[1].

Name	Enpp-1-IN-13

Description	Enpp-1-IN-13 (Compound 1a) is an ectonucleotide pyrophosphatase/phosphodiesterase (ENPP) inhibitor with IC50 values of 1.29 μM and 20.2 μM against ENPP1 and ENPP3, respectively. Enpp-1-IN-13 shows anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Target	IC50: 1.29 μM (ENPP1), 20.2 μM (ENPP3)[1]
In Vitro	Enpp-1-IN-13 (Compound 1a) (100 μM) shows cytotoxic effect with inhibition of 23.0 ± 2.2%, 35.1 ± 0.8% and 30.4 ± 0.1% against HeLa, MCF-7 and 1321N1 cells, respectively[1].
References	[1]. Ullah S, et al. Synthesis, biological evaluation, and docking studies of new pyrazole-based thiourea and sulfonamide derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase. Bioorg Chem. 2020 Jun;99:103783.

Molecular Formula	C₂₈H₂₂ClN₅OS
Molecular Weight	512.03