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422276-47-9

422276-47-9 structure

422276-47-9 structure

Name: EGFR/HER2/CDK9-IN-3
Chemical Name: EGFR/HER2/CDK9-IN-3
CAS Number: 422276-47-9
Molecular Formula: C₂₄H₂₁N₃O₄S₂
Molecular Weight: 479.57
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2022-08-13 16:54:37
Modify Date: 2025-08-25 05:35:19
EGFR/HER2/CDK9-IN-3 (Compound 10) is a potent inhibitor of EGFR/HER2/CDK9 with IC50s of 191.08, 132.65, and 113.98 nM, respectively. EGFR/HER2/CDK9-IN-3 exhibits remarkable antitumor activity[1].

Name	EGFR/HER2/CDK9-IN-3

Description	EGFR/HER2/CDK9-IN-3 (Compound 10) is a potent inhibitor of EGFR/HER2/CDK9 with IC50s of 191.08, 132.65, and 113.98 nM, respectively. EGFR/HER2/CDK9-IN-3 exhibits remarkable antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
References	[1]. El-Azab AS, et al. Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis. Bioorg Chem. 2020;104:104345.

Molecular Formula	C₂₄H₂₁N₃O₄S₂
Molecular Weight	479.57

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