2482310-23-4
2482310-23-4 structure
- Name: Apoptotic agent-3
- Chemical Name: Apoptotic agent-3
- CAS Number: 2482310-23-4
- Molecular Formula: C31H21N5OS
- Molecular Weight: 511.60
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-08-16 15:34:52
- Modify Date: 2024-01-11 17:25:15
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Apoptotic agent-3 (compound 15f) promotes apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway and activation of the Caspase 3 pathway. Apoptotic agent-3 exhibits anti-proliferative activities and can be used for cancer research[1].
| Name | Apoptotic agent-3 |
|---|
| Description | Apoptotic agent-3 (compound 15f) promotes apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway and activation of the Caspase 3 pathway. Apoptotic agent-3 exhibits anti-proliferative activities and can be used for cancer research[1]. |
|---|---|
| Related Catalog | |
| Target |
Caspase 3 Bcl-2 Bax |
| In Vitro | Apoptotic agent-3 (compound 15f) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2 MCF-7 and WI-38 cells (normal human cells) with IC50 values of 1.62, 1.46, 2.04 and 117.9 µM, respectively[1]. .Apoptotic agent-3 (compound 15f) (24 hours) (1.46 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 11.53 folds and 10 folds, respectively, and decreases the level of Bcl-2 by 3.8 folds[1]. Cell Cycle Analysis[1] Cell Line: HepG-2 cells Concentration: 1.46 μM Incubation Time: 24 hours Result: The percentage of cells in the G2-M phase increased while the percentage of cells in G1 phase and S phase decreased. Apoptosis Analysis[1] Cell Line: HepG-2 cells Concentration: 1.46 μM Incubation Time: 24 hours Result: Increased the early apoptosis ratio from 0.69% to 8.25% and increased the late apoptosis ratio from 0.32% to 13.05%. |
| References |
| Molecular Formula | C31H21N5OS |
|---|---|
| Molecular Weight | 511.60 |