2408017-71-8

2408017-71-8 structure

Name: Anticancer agent 57
Chemical Name: Anticancer agent 57
CAS Number: 2408017-71-8
Molecular Formula: C₂₀H₂₁Cl₂NO₂
Molecular Weight: 378.29
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-24 11:23:54
Modify Date: 2024-02-03 10:01:23
Anticancer agent 57 (compound 14) potently inhibits MDA-MB-231, MDA-MB-468, and MCF-7 cell lines, with IC50s of 6.43 ~ 8.00 μM. Anticancer agent 57 induces cell cycle arrest and significantly promotes apoptosis. Anticancer agent 57 inhibits tumor growth in nude mice xenografted with MADMB-231 cells. Anticancer agent 57 can be used for researching triple negative breast cancer (TNBC)[1].

Name	Anticancer agent 57

Description	Anticancer agent 57 (compound 14) potently inhibits MDA-MB-231, MDA-MB-468, and MCF-7 cell lines, with IC50s of 6.43 ~ 8.00 μM. Anticancer agent 57 induces cell cycle arrest and significantly promotes apoptosis. Anticancer agent 57 inhibits tumor growth in nude mice xenografted with MADMB-231 cells. Anticancer agent 57 can be used for researching triple negative breast cancer (TNBC)[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	IC50: 8.00 ± 0.07 μM in MDA-MB-231, 7.30 ± 0.04 μM in MDA-MB-468, 6.43 ± 0.18 μM in MCF-7[1]
References	[1]. Elkhalifa D, et al. Design, synthesis, and validation of novel nitrogen-based chalcone analogs against triple negative breast cancer. Eur J Med Chem. 2020;187:111954.

Molecular Formula	C₂₀H₂₁Cl₂NO₂
Molecular Weight	378.29