2490154-44-2

2490154-44-2 structure

Name: Anti-MRSA agent 5
Chemical Name: Anti-MRSA agent 5
CAS Number: 2490154-44-2
Molecular Formula: C₂₅H₂₂N₄O₄
Molecular Weight: 442.47
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-08-10 19:14:42
Modify Date: 2024-01-16 11:36:31
Anti-MRSA agent is a potent MRSA agent with MIC50 values of 0.38 μg/mL and has low hERG activity with an IC50 values of >40 μM. Anti-MRSA agent also has low cytotoxicity to mammal cells and unlikely to acquire bacterial resistance[1].

Name	Anti-MRSA agent 5

Description	Anti-MRSA agent is a potent MRSA agent with MIC50 values of 0.38 μg/mL and has low hERG activity with an IC50 values of >40 μM. Anti-MRSA agent also has low cytotoxicity to mammal cells and unlikely to acquire bacterial resistance[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	MIC: 0.38 μg/mL (MRSA); IC50: >40 Μm (hERG)
In Vitro	Anti-MRSA agent (B14) is highly selective toxic in bacterial cells. Anti-MRSA agent has marginal inhibitory activities with an IC50 values of exceeding 40 μM. Anti-MRSA agent has strong antibacterial activity for all five clinical isolates of MRSA (NRS-1, NRS-70, NRS-100, NRS-108, NRS-271) with MIC values between < 0.17 and 0.69 μg/mL. Anti-MRSA agent inhibits all three clinical isolates of fluoroquinolone-resistant MRSA (19-25, 19-26, 19-27) and exhibits good potency against VISA[1]. Cell Cytotoxicity Assay Cell Line: A549, MDA-MB-231, PC-3, ABAE. Concentration: 0–400 μM Incubation Time: 48h Result: Showed Anti-MRSA agent has marginal inhibitory activities with anIC50 exceeding 40 μM. B14 also displayed highly selective toxicity toward bacterial cells.
References	[1]. Runzhe Songa, et al, Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity, Bioorg Chem. 2020 Oct;103:104176.

Molecular Formula	C₂₅H₂₂N₄O₄
Molecular Weight	442.47