2550401-76-6

2550401-76-6 structure

Name: Adenosine receptor inhibitor 2
Chemical Name: Adenosine receptor inhibitor 2
CAS Number: 2550401-76-6
Molecular Formula: C₁₇H₂₀BrN₅O₂
Molecular Weight: 406.28
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2022-08-16 10:46:44
Modify Date: 2024-04-03 23:46:00
Adenosine receptor inhibitor 2 (compound 14b) is a potent AR (adenosine receptor) inhibitor. Adenosine receptor inhibitor 2 shows dual affinity toward A1/A2A ARs with higher affinity for the A1- than the A2AAR. Adenosine receptor inhibitor 2 has Ki values of 52.2 nM for the A1AR and 167 nM for the A2AAR[1].

Name	Adenosine receptor inhibitor 2

Description	Adenosine receptor inhibitor 2 (compound 14b) is a potent AR (adenosine receptor) inhibitor. Adenosine receptor inhibitor 2 shows dual affinity toward A1/A2A ARs with higher affinity for the A1- than the A2AAR. Adenosine receptor inhibitor 2 has Ki values of 52.2 nM for the A1AR and 167 nM for the A2AAR[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	A1AR:52.2 ± 8.5 nM (Ki) A2AR:167 ± 22 nM (Ki) hA2B:>1000 nM (Ki) Adenosine A3 receptor:>1000 nM (Ki)
References	[1]. Załuski M, et al. 8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A2A receptors. Design, synthesis and biological evaluation. Bioorg Chem. 2020 Aug;101:104033.

Molecular Formula	C₁₇H₂₀BrN₅O₂
Molecular Weight	406.28