2413974-69-1

2413974-69-1 structure

Name: Mt KARI-IN-5
Chemical Name: Mt KARI-IN-5
CAS Number: 2413974-69-1
Molecular Formula: C₁₄H₁₀N₄O₅S₃
Molecular Weight: 410.45
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-07-02 09:11:42
Modify Date: 2025-08-27 18:43:49
Mt KARI-IN-5 (compound 6c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 4.72 μM. Mt KARI-IN-5 has inhibitory activity against Mtb H37Rv (MIC = 1.56 μM) and low cytotoxicity (HEK IC50 > 64 μg/mL)[1]

Name	Mt KARI-IN-5

Description	Mt KARI-IN-5 (compound 6c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 4.72 μM. Mt KARI-IN-5 has inhibitory activity against Mtb H37Rv (MIC = 1.56 μM) and low cytotoxicity (HEK IC50 > 64 μg/mL)[1]
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Ki: 4.72 μM (Mtb KARI)[1]
References	[1]. Krishna VS, et al. Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178.

Molecular Formula	C₁₄H₁₀N₄O₅S₃
Molecular Weight	410.45