1003600-48-3
1003600-48-3 structure
- Name: (-)-Cleistenolide
- Chemical Name: (-)-Cleistenolide
- CAS Number: 1003600-48-3
- Molecular Formula: C18H18O8
- Molecular Weight: 362.33
- Catalog: Research Areas Cancer
- Create Date: 2022-07-10 16:23:23
- Modify Date: 2025-08-26 23:07:32
-
(-)-Cleistenolide is a α,β-unsaturated δ-lactone isolated from Cleistochlamys kirkii Oliver. (-)-Cleistenolide has antibacterial and antitumor activity[1].
| Name | (-)-Cleistenolide |
|---|
| Description | (-)-Cleistenolide is a α,β-unsaturated δ-lactone isolated from Cleistochlamys kirkii Oliver. (-)-Cleistenolide has antibacterial and antitumor activity[1]. |
|---|---|
| Related Catalog | |
| In Vitro | (-)-Cleistenolide (compound 1) exhibits potent cytotoxicity against cancer cell lines and low cytotoxicity in normal cells MRC-5[1]. Cell Cytotoxicity Assay Cell Line: K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB 231, HeLa, A549 and MRC-5[1] Concentration: 0-100 μM Incubation Time: Result: Exhibited potent cytotoxicity against cancer cell lines with IC50s of 7.65 μM, 1.21 μM, 14.22 μM, 36.94 μM, 26.07 μM, 2.25 μM, 7.32 μM and 16.34 μM in K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB 231, HeLa and A549, respectively; and had low cytotoxicity in normal cells MRC-5 with an IC50 over 100 μM. |
| References |
| Molecular Formula | C18H18O8 |
|---|---|
| Molecular Weight | 362.33 |