2700035-54-5

2700035-54-5 structure

Name: HDAC/HSP90-IN-3
Chemical Name: HDAC/HSP90-IN-3
CAS Number: 2700035-54-5
Molecular Formula: C₂₆H₃₃N₅O₆
Molecular Weight: 511.57
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2022-07-01 12:47:37
Modify Date: 2024-01-14 17:26:38
HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1[1].

Name	HDAC/HSP90-IN-3

Description	HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Cell Cycle/DNA Damage >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HSP90:0.83 μM (IC50, fungal Hsp90) HDAC:0.91 μM (IC50, fungal HDACs) human HDAC:3.0 μM (IC50, human HDACs) HSP90:19.52 μM (IC50, human Hsp90)
In Vitro	HDAC/HSP90-IN-3 (compound J5) significantly down-regulates the adherence-related genes (such as ALS3, HWP1, EAP1, BCR1), and down-regulates the expression of ERG11 and CDR1[1].
References	[1]. Li C, Tu J, Han G, Liu N, Sheng C. Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans. Eur J Med Chem. 2022 Jan 5;227:113961.

Molecular Formula	C₂₆H₃₃N₅O₆
Molecular Weight	511.57