2634714-79-5

2634714-79-5 structure
2634714-79-5 structure
  • Name: CB2R probe 1
  • Chemical Name: CB2R probe 1
  • CAS Number: 2634714-79-5
  • Molecular Formula: C36H42N4O4
  • Molecular Weight: 594.74
  • Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
  • Create Date: 2022-09-10 10:58:00
  • Modify Date: 2024-03-31 11:08:28
  • CB2R probe 1 is a safe and green CB2R (cannabinoid 2 receptor) fluorescent probe with an Ki of 130 nM. CB2R probe 1 shows low cytotoxicity in cancer cells[1].

Name CB2R probe 1
Description CB2R probe 1 is a safe and green CB2R (cannabinoid 2 receptor) fluorescent probe with an Ki of 130 nM. CB2R probe 1 shows low cytotoxicity in cancer cells[1].
Related Catalog
Target

cannabinoid type-2 receptors:130 nM (Ki)

In Vitro CB2R probe 1 (compound 28) (100 nM; 24 h) shows low cytotoxicity with IC50s of 1.6, 1.4, 1.4, 1.1, 2.6, 0.55, 2.0, 2.4, 2.8 nM for PANC1, U2OS, HT29, HT29-DX, U87AD, PC3, CB2R-HEK293, MCF7, MCFT-DX cells, respectively[1].
References

[1]. Spinelli F, et al. Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R). Eur J Med Chem. 2020 Feb 15;188:112037.

Molecular Formula C36H42N4O4
Molecular Weight 594.74