1007385-99-0
1007385-99-0 structure
- Name: (R,S′)-MNF
- Chemical Name: (R,S′)-MNF
- CAS Number: 1007385-99-0
- Molecular Formula: C22H25NO4
- Molecular Weight: 367.445
- Create Date: 2022-07-17 10:07:35
- Modify Date: 2025-08-26 00:57:07
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(R,S′)-MNF is a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist, inhibits proliferation of PDAC cell lines (IC50=0.11 uM, PANC-1 cells).(R,S′)-MNF is a biased β2-AR agonist that selectively signals through Gαs and does not recruit β-arrestin-2.(R,S′)-MNF attenuates pro-oncogenic signaling and cellular proliferation in PANC-1 cells.(R,S′)-MNF (1 uM) significantly decreased ERK phosphorylation stimulated by the GPR55 ligand O-1602, (R,S′)-MNF is an effective inhibitor of GPR55 internalization and signaling.(R,S′)-MNF (20-40 mg/Kg) reduces PANC-1 tumor growth in a mouse xenograft model.
| Name | (R,S′)-MNF |
|---|
| Description | (R,S′)-MNF is a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist, inhibits proliferation of PDAC cell lines (IC50=0.11 uM, PANC-1 cells).(R,S′)-MNF is a biased β2-AR agonist that selectively signals through Gαs and does not recruit β-arrestin-2.(R,S′)-MNF attenuates pro-oncogenic signaling and cellular proliferation in PANC-1 cells.(R,S′)-MNF (1 uM) significantly decreased ERK phosphorylation stimulated by the GPR55 ligand O-1602, (R,S′)-MNF is an effective inhibitor of GPR55 internalization and signaling.(R,S′)-MNF (20-40 mg/Kg) reduces PANC-1 tumor growth in a mouse xenograft model. |
|---|---|
| References | 1. Artur Wnorowski, et al. Sci Rep. 2022 Mar 7;12(1):3618. |
| Molecular Formula | C22H25NO4 |
|---|---|
| Molecular Weight | 367.445 |