2411771-95-2
2411771-95-2 structure
- Name: JS25
- Chemical Name: JS25
- CAS Number: 2411771-95-2
- Molecular Formula: C29H24N4O4S
- Molecular Weight: 524.595
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Btk
- Create Date: 2022-07-07 23:25:40
- Modify Date: 2024-01-06 14:40:10
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JS25 is a potent, selective, covalent TEC family of non-receptor tyrosine kinases (BTK, ITK, TXK and BMX) inhibitor with IC50 of 3.5 and 5.8 nM for BMX and BTK, respectively.JS25 displays a strong binding affinity against all the members of TEC family, covalently inhibits BMX at Cys496. JS25 demonstrates intracellular target engagement in HEK293 cells (IC50=44.8 nM), 10 times greater than BMX-IN-1.JS25 inhibits androgen-receptor positive prostate-cancer cells with GI50 of 6.6 uM.JS25 shows synergistic anti-proliferative activity in LNCaP cells in combination with AKT1/2 (AKT inhibitor), Flutamide (androgen receptor antagonist) and LY293002 (PI3K inhibitor).
| Name | JS25 |
|---|
| Description | JS25 is a potent, selective, covalent TEC family of non-receptor tyrosine kinases (BTK, ITK, TXK and BMX) inhibitor with IC50 of 3.5 and 5.8 nM for BMX and BTK, respectively.JS25 displays a strong binding affinity against all the members of TEC family, covalently inhibits BMX at Cys496. JS25 demonstrates intracellular target engagement in HEK293 cells (IC50=44.8 nM), 10 times greater than BMX-IN-1.JS25 inhibits androgen-receptor positive prostate-cancer cells with GI50 of 6.6 uM.JS25 shows synergistic anti-proliferative activity in LNCaP cells in combination with AKT1/2 (AKT inhibitor), Flutamide (androgen receptor antagonist) and LY293002 (PI3K inhibitor). |
|---|---|
| References | 1. João D Seixas, et al. RSC Chem Biol. 2020 Aug 28;1(4):251-262. |
| Molecular Formula | C29H24N4O4S |
|---|---|
| Molecular Weight | 524.595 |