2232180-74-2
2232180-74-2 structure
- Name: BT173
- Chemical Name: BT173
- CAS Number: 2232180-74-2
- Molecular Formula: C18H12BrN3O2
- Molecular Weight: 382.217
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK DYRK
- Create Date: 2022-07-19 16:22:29
- Modify Date: 2024-01-13 14:16:07
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BT173 is a small molecule allosteric inhibitor of HIPK2-Smad3 interaction, specifically inhibits the TGF-β1/Smad3 pathway.BT173 disrupts HIPK2-Smad3 protein-protein interaction (PPI) without significant inhibition of HIPK2 kinase activity or inhibition of p53 activation.BT173 inhibits Smad3 phosphorylation in human kidney cells in vitro.BT173 significantly attenuated renal fibrosis development in the UUO mice, significantly decreased Smad3 phosphorylation and α-SMA expression in the UUO kidneys.Treatment of BT173 ameliorated kidney fibrosis in Tg26 mice.
| Name | BT173 |
|---|
| Description | BT173 is a small molecule allosteric inhibitor of HIPK2-Smad3 interaction, specifically inhibits the TGF-β1/Smad3 pathway.BT173 disrupts HIPK2-Smad3 protein-protein interaction (PPI) without significant inhibition of HIPK2 kinase activity or inhibition of p53 activation.BT173 inhibits Smad3 phosphorylation in human kidney cells in vitro.BT173 significantly attenuated renal fibrosis development in the UUO mice, significantly decreased Smad3 phosphorylation and α-SMA expression in the UUO kidneys.Treatment of BT173 ameliorated kidney fibrosis in Tg26 mice. |
|---|---|
| References | 1. Liu R, et al. J Am Soc Nephrol. 2017 Jul;28(7):2133-2143. 2. Caescu CI, et al. Arterioscler Thromb Vasc Biol. 2021 Sep;41(9):2483-2493. |
| Molecular Formula | C18H12BrN3O2 |
|---|---|
| Molecular Weight | 382.217 |