2051196-02-0
2051196-02-0 structure
- Name: FL-18
- Chemical Name: FL-18
- CAS Number: 2051196-02-0
- Molecular Formula: C22H21N3O3
- Molecular Weight: 375.428
- Create Date: 2022-07-01 17:24:05
- Modify Date: 2024-04-08 18:13:42
-
FL-18 (p97 inhibitor FL-18) is is the first small-molecule covalent inhibitor of VCP/p97 AAA ATPase with IC50 of 59.3 nM, capable of covalent engagement of p97 with proteome-wide selectivity.FL-18 showed better inhibition potency than NMS-873, a well-known p97 inhibitor.FL-18 covalently modified C522 residue in p97 and showed potent enzymatic inhibition.FL-18 showed potent inhibition towards U87MG glioma cancer cells (IC50=31 nM).FL-18 inhibited the p97 activity and induced aggregation of ubiquitinated proteins in U87MG cells.
| Name | FL-18 |
|---|
| Description | FL-18 (p97 inhibitor FL-18) is is the first small-molecule covalent inhibitor of VCP/p97 AAA ATPase with IC50 of 59.3 nM, capable of covalent engagement of p97 with proteome-wide selectivity.FL-18 showed better inhibition potency than NMS-873, a well-known p97 inhibitor.FL-18 covalently modified C522 residue in p97 and showed potent enzymatic inhibition.FL-18 showed potent inhibition towards U87MG glioma cancer cells (IC50=31 nM).FL-18 inhibited the p97 activity and induced aggregation of ubiquitinated proteins in U87MG cells. |
|---|---|
| References | 1. Zi Ye, et al. Acta Pharm Sin B. 2022 Feb;12(2):982-989. |
| Molecular Formula | C22H21N3O3 |
|---|---|
| Molecular Weight | 375.428 |