2487253-25-6
2487253-25-6 structure
- Name: DL-175
- Chemical Name: DL-175
- CAS Number: 2487253-25-6
- Molecular Formula: C17H14ClNO2
- Molecular Weight: 299.754
- Create Date: 2022-07-27 13:38:23
- Modify Date: 2024-09-08 20:46:23
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DL-175 is a potent and selective biased GPR84 agonist with EC50 of 33 nM.DL-175 exhibits no significant activity in a panel of 168 other GPCRs.DL-175 display significantly biased signaling across GPR84-overexpressing cells, primary murine macrophages, and human U937 cells.DL-175 markedly different abilities to induce chemotaxis in human myeloid cells, while causing similar levels of phagocytosis enhancement.
| Name | DL-175 |
|---|
| Description | DL-175 is a potent and selective biased GPR84 agonist with EC50 of 33 nM.DL-175 exhibits no significant activity in a panel of 168 other GPCRs.DL-175 display significantly biased signaling across GPR84-overexpressing cells, primary murine macrophages, and human U937 cells.DL-175 markedly different abilities to induce chemotaxis in human myeloid cells, while causing similar levels of phagocytosis enhancement. |
|---|---|
| References | 1. Lucy D, et al. ACS Chem Biol. 2019 Sep 20;14(9):2055-2064. |
| Molecular Formula | C17H14ClNO2 |
|---|---|
| Molecular Weight | 299.754 |