2484771-19-7
2484771-19-7 structure
- Name: HF50731
- Chemical Name: HF50731
- CAS Number: 2484771-19-7
- Molecular Formula: C26H46N4
- Molecular Weight: 414.682
- Catalog: Signaling Pathways Anti-infection HIV
- Create Date: 2022-07-01 16:13:09
- Modify Date: 2025-08-25 18:59:15
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HF50731 (HF-50731) is a novel potent, selective CXCR4 antagonist with Ki of 19.8 nM in the CXCR4 competitive binding assay.HF50731 significantly inhibited SDF-1α-induced calcium mobilization (IC50=621 nM) and cell migration, and blocked HIV-1 infection via antagonizing CXCR4 coreceptor function (IC50=1.5 uM).The structure-activity relationship analysis demonstrated that HF50731 could primarily occupy the minor subpocket of CXCR4 and partially bind in the major subpocket by interacting with residues W94, D97, D171, and E288.
| Name | HF50731 |
|---|
| Description | HF50731 (HF-50731) is a novel potent, selective CXCR4 antagonist with Ki of 19.8 nM in the CXCR4 competitive binding assay.HF50731 significantly inhibited SDF-1α-induced calcium mobilization (IC50=621 nM) and cell migration, and blocked HIV-1 infection via antagonizing CXCR4 coreceptor function (IC50=1.5 uM).The structure-activity relationship analysis demonstrated that HF50731 could primarily occupy the minor subpocket of CXCR4 and partially bind in the major subpocket by interacting with residues W94, D97, D171, and E288. |
|---|---|
| References | 1. Xiong Fang, et al. Eur J Med Chem. 2020 Aug 15;200:112410. |
| Molecular Formula | C26H46N4 |
|---|---|
| Molecular Weight | 414.682 |