2342614-58-6
2342614-58-6 structure
- Name: CTCB-405
- Chemical Name: CTCB-405
- CAS Number: 2342614-58-6
- Molecular Formula: C18H19Cl2N3O
- Molecular Weight: 364.27
- Create Date: 2022-07-01 17:59:31
- Modify Date: 2024-04-08 18:33:36
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CTCB-405 (CTCB405) is a small molecule allosteric inhibitor of T. brucei phosphofructokinase (TbPFK) with IC50 of 0.18 uM, ITC Kd of 92 nM, no significant inhibition of human PFKs.CTCB-405 demonstrated in vitro parasite killing potency of the bloodstream form of T. brucei strain Lister 427 (EC50=0.37 uM).CTCB-405 (50, 100 mg/kg) clear parasites in a stage 1 model of HAT infection with 1-day oral dosing and show reduction of parasitaemia in the brain in a pleiomorphic model.
| Name | CTCB-405 |
|---|
| Description | CTCB-405 (CTCB405) is a small molecule allosteric inhibitor of T. brucei phosphofructokinase (TbPFK) with IC50 of 0.18 uM, ITC Kd of 92 nM, no significant inhibition of human PFKs.CTCB-405 demonstrated in vitro parasite killing potency of the bloodstream form of T. brucei strain Lister 427 (EC50=0.37 uM).CTCB-405 (50, 100 mg/kg) clear parasites in a stage 1 model of HAT infection with 1-day oral dosing and show reduction of parasitaemia in the brain in a pleiomorphic model. |
|---|---|
| References | 1. Iain W McNae, et al. Nat Commun. 2021 Feb 16;12(1):1052. |
| Molecular Formula | C18H19Cl2N3O |
|---|---|
| Molecular Weight | 364.27 |