2267290-96-8
2267290-96-8 structure
- Name: QC-01–175
- Chemical Name: QC-01–175
- CAS Number: 2267290-96-8
- Molecular Formula: C33H34N6O7
- Molecular Weight: 626.670
- Create Date: 2022-07-02 01:49:16
- Modify Date: 2024-01-09 08:39:14
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QC-01-175 is a hetero-bifunctional molecule designed to engage both tau and Cereblon (CRBN) to trigger tau ubiquitination and proteasomal degradation (tau PROTAC).QC-01–175 effected clearance of tau in frontotemporal dementia (FTD) patient-derived neuronal cell models, with minimal effect on tau from neurons of healthy controls.QC-01–175 also rescued stress vulnerability in FTD neurons, phenocopying CRISPR-mediated MAPT-knockout.
| Name | QC-01–175 |
|---|
| Description | QC-01-175 is a hetero-bifunctional molecule designed to engage both tau and Cereblon (CRBN) to trigger tau ubiquitination and proteasomal degradation (tau PROTAC).QC-01–175 effected clearance of tau in frontotemporal dementia (FTD) patient-derived neuronal cell models, with minimal effect on tau from neurons of healthy controls.QC-01–175 also rescued stress vulnerability in FTD neurons, phenocopying CRISPR-mediated MAPT-knockout. |
|---|---|
| References | 1. M Catarina Silva, et al. Elife. 2019 Mar 25;8:e45457. |
| Molecular Formula | C33H34N6O7 |
|---|---|
| Molecular Weight | 626.670 |