1383420-08-3
1383420-08-3 structure
- Name: Rencofilstat
- Chemical Name: Rencofilstat
- CAS Number: 1383420-08-3
- Molecular Formula: C67H122N12O13
- Molecular Weight: 1303.784
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
- Create Date: 2022-07-11 19:21:57
- Modify Date: 2025-08-25 21:12:33
-
Rencofilstat (CRV431) is a non-immunosuppressive analogue of cyclosporine A and pan-cyclophilin inhibitor, potently inhibits cyclophilin isoforms A, B, D, and G with IC50 of 1-7 nM.Rencofilstat (CRV431) is more than 13 times more potent than the parent compound, cyclosporine A (CsA).Rencofilstat (CRV431) inhibits liver HBV DNA and HBsAg, reduces liver HBV DNA levels and moderately decreased serum HBsAg levels in HBV transgenic mouse model.Rencofilstat (CRV431) shows potential as a drug candidate for chronic liver diseases.
| Name | Rencofilstat |
|---|
| Description | Rencofilstat (CRV431) is a non-immunosuppressive analogue of cyclosporine A and pan-cyclophilin inhibitor, potently inhibits cyclophilin isoforms A, B, D, and G with IC50 of 1-7 nM.Rencofilstat (CRV431) is more than 13 times more potent than the parent compound, cyclosporine A (CsA).Rencofilstat (CRV431) inhibits liver HBV DNA and HBsAg, reduces liver HBV DNA levels and moderately decreased serum HBsAg levels in HBV transgenic mouse model.Rencofilstat (CRV431) shows potential as a drug candidate for chronic liver diseases. |
|---|---|
| References | 1. Gallay P, et al. PLoS One. 2019 Jun 10;14(6):e0217433. 2. Kuo J, et al. J Pharmacol Exp Ther. 2019 Nov;371(2):231-241. 3. Trepanier DJ, et al. J Pharm Pharm Sci. 2018;21(1s):335s-348s. |
| Molecular Formula | C67H122N12O13 |
|---|---|
| Molecular Weight | 1303.784 |