1235486-15-3
1235486-15-3 structure
- Name: EC-11716
- Chemical Name: EC-11716
- CAS Number: 1235486-15-3
- Molecular Formula: C23H28ClN5O3
- Molecular Weight: 457.959
- Create Date: 2022-07-11 17:28:20
- Modify Date: 2023-01-04 16:49:19
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EC-11716 (EC/11716) is a novel mycobacterium tuberculosis gyrase inhibitor with potent anti-tubercular activity (MIC 0.38 uM, M. tuberculosis H37Rv).EC/11716 is active against M. abscessus subspecies and clinical isolates, maintains comparable activity against a panel of clinical isolates covering the M. abscessus complex.EC/11716 is effective against M. abscessus biofilms (MIC 0.78 uM), with better bactericidal activity against biofilms than moxifloxacin.EC/11716 is active against M. abscessus in vivo.
| Name | EC-11716 |
|---|
| Description | EC-11716 (EC/11716) is a novel mycobacterium tuberculosis gyrase inhibitor with potent anti-tubercular activity (MIC 0.38 uM, M. tuberculosis H37Rv).EC/11716 is active against M. abscessus subspecies and clinical isolates, maintains comparable activity against a panel of clinical isolates covering the M. abscessus complex.EC/11716 is effective against M. abscessus biofilms (MIC 0.78 uM), with better bactericidal activity against biofilms than moxifloxacin.EC/11716 is active against M. abscessus in vivo. |
|---|---|
| References | 1. Uday S Ganapathy, et al. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0151421. |
| Molecular Formula | C23H28ClN5O3 |
|---|---|
| Molecular Weight | 457.959 |