1081317-31-8
1081317-31-8 structure
- Name: DA-0218
- Chemical Name: DA-0218
- CAS Number: 1081317-31-8
- Molecular Formula: C36H37N3O2
- Molecular Weight: 543.711
- Create Date: 2022-07-01 11:02:36
- Modify Date: 2023-01-15 13:30:39
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DA-0218 (DA0218) is a novel potent, selective Nav1.7 inhibitor, inhibits sodium currents in Nav1.7-expressing human embryonic kidney 293 cells with IC50 of 0.74 uM.DA-0218 has no effect on sodium currents in Nav1.5-transfected human embryonic kidney 293 cells in patch-clamp experiments.DA-0218 shows analgesic activity predominantly in phase II in formalin-induced inflammatory pain mouse model.DA-0218 produced acute reduction in paclitaxel-induced mechanical allodynia, and inhibited histamine-induced acute itch and lymphoma-induced chronic itch.
| Name | DA-0218 |
|---|
| Description | DA-0218 (DA0218) is a novel potent, selective Nav1.7 inhibitor, inhibits sodium currents in Nav1.7-expressing human embryonic kidney 293 cells with IC50 of 0.74 uM.DA-0218 has no effect on sodium currents in Nav1.5-transfected human embryonic kidney 293 cells in patch-clamp experiments.DA-0218 shows analgesic activity predominantly in phase II in formalin-induced inflammatory pain mouse model.DA-0218 produced acute reduction in paclitaxel-induced mechanical allodynia, and inhibited histamine-induced acute itch and lymphoma-induced chronic itch. |
|---|---|
| References | 1. Sharat Chandra, et al. Anesthesiology. 2020 Sep;133(3):611-627. |
| Molecular Formula | C36H37N3O2 |
|---|---|
| Molecular Weight | 543.711 |