2490699-40-4

2490699-40-4 structure

Name: LDHA/PDKs-IN-1
Chemical Name: LDHA/PDKs-IN-1
CAS Number: 2490699-40-4
Molecular Formula: C₁₉H₂₁FN₂O₄
Molecular Weight: 360.38
Catalog: Signaling Pathways PI3K/Akt/mTOR PDK-1
Create Date: 2022-06-04 13:36:45
Modify Date: 2024-01-02 18:58:31
LDHA/PDKs-IN-1 (compound 20e) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 0.8 and 0.15 μM, respectively. LDHA/PDKs-IN-1 reduces A549 cell proliferation with an EC50 of 13.2 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-1 has the potential for the research of cancer diseases[1].

Name	LDHA/PDKs-IN-1

Description	LDHA/PDKs-IN-1 (compound 20e) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 0.8 and 0.15 μM, respectively. LDHA/PDKs-IN-1 reduces A549 cell proliferation with an EC50 of 13.2 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-1 has the potential for the research of cancer diseases[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> PDK-1 Research Areas >> Cancer
References	[1]. Xiang S, et al. Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation. Eur J Med Chem. 2020;203:112579.

Molecular Formula	C₁₉H₂₁FN₂O₄
Molecular Weight	360.38