1807631-83-9
1807631-83-9 structure
- Name: CJJ300
- Chemical Name: CJJ300
- CAS Number: 1807631-83-9
- Molecular Formula: C30H33N3
- Molecular Weight: 435.60
- Catalog: Research Areas Cancer
- Create Date: 2022-07-11 16:11:31
- Modify Date: 2025-09-02 13:27:48
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CJJ300 is a transforming growth factor-β (TGF-β) inhibitor with an IC50 of 5.3 µM. CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex[1].
| Name | CJJ300 |
|---|
| Description | CJJ300 is a transforming growth factor-β (TGF-β) inhibitor with an IC50 of 5.3 µM. CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex[1]. |
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| Related Catalog | |
| Target |
IC50: 5.3 µM (TGF-β1-induced luciferase)[1] |
| In Vitro | CJJ300 disturbs protein-protein interactions and prevents TGF-β receptor dimerization (IC50 = 23.6 ± 5.8 µM)[1]. CJJ300 (0-80 µM, 2 h) inhibits the phosphorylation of intracellular mediators in the downstream TGF-β signaling pathways, and suppresses the expression of markers of EMT (epithelial-mesenchymal transition) without cytotoxicity[1]. CJJ300 suppresses TGF-β induced cell migration[1]. Western Blot Analysis[1] Cell Line: Human A549 lung epithelial cells Concentration: 20, 40, and 80 µM Incubation Time: 2 h Result: Significantly attenuated the increasement of P-Smad2/Smad3, P-Erk1/2 and P-Akt induced by TGF-β. Down regulated the expression of EMT-associated proteins, including fibronectin, α-SMA and MMP-2 in a dose-dependent manner. |
| References |
| Molecular Formula | C30H33N3 |
|---|---|
| Molecular Weight | 435.60 |