329706-62-9
329706-62-9 structure
- Name: AG6033
- Chemical Name: AG6033
- CAS Number: 329706-62-9
- Molecular Formula: C30H23N5O4
- Molecular Weight: 517.53
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-06-24 14:09:31
- Modify Date: 2025-08-25 21:25:07
-
AG6033 is a potential novel CRBN modulator. AG6033 suppresses various tumor cells by modulating the interactions between CRBN and various antitumor target proteins. AG6033 can cause GSPT1 and IKZF1 degradation. AG6033 induces CRBN-dependent cytotoxic effect[1].
| Name | AG6033 |
|---|
| Description | AG6033 is a potential novel CRBN modulator. AG6033 suppresses various tumor cells by modulating the interactions between CRBN and various antitumor target proteins. AG6033 can cause GSPT1 and IKZF1 degradation. AG6033 induces CRBN-dependent cytotoxic effect[1]. |
|---|---|
| Related Catalog | |
| Target |
CRBN |
| In Vitro | AG6033 (0.064-40 μM, 4 h) has potent inhibition ability against A549[1]. AG6033 (1-10 μM, 24 h) significantly promotes apoptosis of A549 cells in a dose-dependent manner[1]. Cell Proliferation Assay Cell Line: A549 cells[1] Concentration: 0.064 μM, 0.32 μM, 1.6 μM, 8 μM, and 40 μM Incubation Time: 4 h Result: Exhibited potent inhibitory ability against A549, with an IC50 of 0.853 μM. Apoptosis Analysis Cell Line: A549 cells[1] Concentration: 1 μM, 5 μM, 10 μM Incubation Time: 24 h Result: Significantly promoted apoptosis of A549 cells in a dose-dependent manner, and the proportion of late apoptotic cells were 5.39%, 22.0%, and 29.1%, respectively. |
| References |
| Molecular Formula | C30H23N5O4 |
|---|---|
| Molecular Weight | 517.53 |