2762278-95-3

2762278-95-3 structure

Name: ZDLD13
Chemical Name: ZDLD13
CAS Number: 2762278-95-3
Molecular Formula: C₁₈H₁₄N₄O
Molecular Weight: 302.33
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-05-20 18:17:58
Modify Date: 2024-01-12 20:58:01
ZDLD13, a β-carboline, is an orally active and selective CDK4/CycD3 inhibitor with an IC50 value of 0.38 μM. ZDLD13 exhibits potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. ZDLD13 shows significant tumor growth inhibition in HCT116 tumor xenograft model[1].

Name	ZDLD13

Description	ZDLD13, a β-carboline, is an orally active and selective CDK4/CycD3 inhibitor with an IC50 value of 0.38 μM. ZDLD13 exhibits potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. ZDLD13 shows significant tumor growth inhibition in HCT116 tumor xenograft model[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK4/CycD3:0.38 μM (IC50)
References	[1]. Deping Li, et al. Facile synthesis of C1-substituted β-carbolines as CDK4 inhibitors for the treatment of cancer. Bioorg Chem. 2022 Apr;121:105659.

Molecular Formula	C₁₈H₁₄N₄O
Molecular Weight	302.33