2516246-24-3
2516246-24-3 structure
- Name: FtsZ-IN-1
- Chemical Name: FtsZ-IN-1
- CAS Number: 2516246-24-3
- Molecular Formula: C26H32IN3
- Molecular Weight: 513.46
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2022-06-30 23:43:17
- Modify Date: 2025-08-25 10:48:09
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FtsZ-IN-1 is a potent FtsZ inhibitor with quinolinium ring. FtsZ-IN-1 has stronger antibacterial activity against Gram-positive bacteria with MICs of 0.5-8 μg/mL. FtsZ-IN-1 significantly causes cell elongation of B. subtilis by enhancing FtsZ polymerization. FtsZ-IN-1 exhibits low hemolytic toxicity and low tendency to induce drug resistance. FtsZ-IN-1 has against drug-resistant bacteria activity[1].
| Name | FtsZ-IN-1 |
|---|
| Description | FtsZ-IN-1 is a potent FtsZ inhibitor with quinolinium ring. FtsZ-IN-1 has stronger antibacterial activity against Gram-positive bacteria with MICs of 0.5-8 μg/mL. FtsZ-IN-1 significantly causes cell elongation of B. subtilis by enhancing FtsZ polymerization. FtsZ-IN-1 exhibits low hemolytic toxicity and low tendency to induce drug resistance. FtsZ-IN-1 has against drug-resistant bacteria activity[1]. |
|---|---|
| Related Catalog | |
| Target |
FtsZ[1] |
| In Vitro | FtsZ-IN-1 (compound A3) inhibits effectively the growth of S. aureus with MICs of 0.5-1 μg/mL, and generally displays less antibacterial potency against most Gram-negative bacteria tested such as E. coli ATCC 8739 (MIC = 64 μg/mL) and P. Aeruginosa ATCC 27853 (MIC >64 μg/mL)[1]. FtsZ-IN-1 exhibits MBCs of 4-8 μg/mL and MICs of 1-4 μg/mL against S. aureus, B. subtilis and E. faecium[1]. FtsZ-IN-1 (0-24 μg/mL; 24 hours) inhibits the growth of S. aureus in a bacteriostatic mode at 1×, 2×, 4× MIC concentrations, and kills S. aureus at 8× MIC concentration[1]. FtsZ-IN-1 can restore the antibacterial activity of methicillin against MRSA in a synergistic manner, with MIC of 2 μg/mL[1]. FtsZ-IN-1 (2 μg/mL; 4 hours) can enlarge cell size of B. subtilis and inhibits bacterial cell division[1]. FtsZ-IN-1 (0-15 μg/mL; 48 hours) exhibits IC50s of 12.77 and 9.42 μg/mL in L929 and HK-2 cells[1]. FtsZ-IN-1 (2 μg/mL) can effectively delay the induction of drug resistance[1]. Cell Cytotoxicity Assay Cell Line: L929 and HK-2 cells[1] Concentration: 0-15 μg/mL Incubation Time: 48 hours Result: Exhibited IC50s of 12.77 and 9.42 μg/mL in L929 and HK-2 cells. |
| In Vivo | FtsZ-IN-1 (1-64 μg/mL; 1 hour) exhibits low hemolytic toxicity in mice erythrocytes (from Kunming mice) with IC5 of 64 μg/mL[1]. |
| References |
| Molecular Formula | C26H32IN3 |
|---|---|
| Molecular Weight | 513.46 |