2757957-25-6
2757957-25-6 structure
- Name: ABAI-30
- Chemical Name: ABAI-30
- CAS Number: 2757957-25-6
- Molecular Formula: C17H13N7O2
- Molecular Weight: 347.33
- Create Date: 2022-05-21 09:52:41
- Modify Date: 2024-01-07 12:30:05
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ABAI-30 is a potent and orally active anti-inflammatory agent. ABAI-30 effectively inhibits NO production in lipopolysaccharide (LPS) induced RAW264.7 cells[1].
| Name | ABAI-30 |
|---|
| Description | ABAI-30 is a potent and orally active anti-inflammatory agent. ABAI-30 effectively inhibits NO production in lipopolysaccharide (LPS) induced RAW264.7 cells[1]. |
|---|---|
| Related Catalog | |
| In Vitro | In RAW264.7 cells, ABAI-30 (10-40 μM) inhibits the TLR4-pp65 and NLRP3-caspase-1 signaling pathway, thus leading to the downregulation of IL6, IL-1β and TNFα at both transcriptional and translational levels[1]. |
| In Vivo | In a dextran sulfate sodium (DSS)-induced colitis mouse model, ABAI-30 (25 mg/kg; oral administration; for 5 days) demonstrates high in vivo anti-inflammatory efficacy without causing obvious toxicity[1]. |
| References |
| Molecular Formula | C17H13N7O2 |
|---|---|
| Molecular Weight | 347.33 |