71117-97-0

71117-97-0 structure

Name: Isogarcinol
Chemical Name: Isogarcinol
CAS Number: 71117-97-0
Molecular Formula: C₃₈H₅₀O₆
Molecular Weight: 602.80
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2022-05-08 11:17:15
Modify Date: 2024-04-07 09:19:28
Isogarcinol (Cambogin) is a potent AChE and BChE inhibitor, with IC50 values of 1.13 and 8.30 μM, respectively. Isogarcinol also shows leishmanicidal activity, with an IC50 of 0.33 μM against L. donovani[1].

Name	Isogarcinol
Synonyms	Isogarcinol 9H-4a,8-Methano-2H-cycloocta[b]pyran-9,11-dione, 10-(3,4-dihydroxybenzoyl)-3,4,5,6,7,8-hexahydro-2,2,7,7-tetramethyl-3,6,8-tris(3-methyl-2-buten-1-yl)-, (3S,4aS,6R,8R)- iso-Xanthochymol (1S,3S,9R,11R)-7-(3,4-Dihydroxybenzoyl)-4,4,10,10-tetramethyl-3,9,11-tris(3-methyl-2-buten-1-yl)-5-oxatricyclo[7.3.1.01,6]tridec-6-ene-8,13-dione

Description	Isogarcinol (Cambogin) is a potent AChE and BChE inhibitor, with IC50 values of 1.13 and 8.30 μM, respectively. Isogarcinol also shows leishmanicidal activity, with an IC50 of 0.33 μM against L. donovani[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Neuronal Signaling >> AChE
Target	AChE:1.13 ± 0.0 μM (IC50) BChE:8.30 ± 0.0 μM (IC50) Leishmania:0.33 μM (IC50)
References	[1]. Lenta BN, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules. 2007 Jul 20;12(8):1548-57.