1443994-46-4

1443994-46-4 structure

Name: Mongersen
Chemical Name: Mongersen
CAS Number: 1443994-46-4
Molecular Formula: C₂₀₀H₂₆₁N₆₉O₁₀₇P₂₀S₂₀
Molecular Weight: 6604
Catalog: Signaling Pathways Stem Cell/Wnt TGF-beta/Smad
Create Date: 2022-04-07 20:31:29
Modify Date: 2026-06-30 17:48:13
Mongersen is a 21-mer phosphorothioate antisense oligonucleotide targeting the mRNA of the Smad7 protein, thus leading to suppression of TGF-β1 pathways and remission of Crohn's disease.

Name	Mongersen

Description	Mongersen is a 21-mer phosphorothioate antisense oligonucleotide targeting the mRNA of the Smad7 protein, thus leading to suppression of TGF-β1 pathways and remission of Crohn's disease.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad Research Areas >> Inflammation/Immunology
References	[1]. Monteleone G, Neurath MF, Ardizzone S, et al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease. N Engl J Med. 2015;372(12):1104-1113.