1428341-65-4

1428341-65-4 structure

Name: LG308
Chemical Name: LG308
CAS Number: 1428341-65-4
Molecular Formula: C₁₉H₁₇FN₂O
Molecular Weight: 308.35
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-04-17 14:19:09
Modify Date: 2024-01-05 12:22:44
LG308 is a novel synthetic compound with antimicrotubule activity. LG308 induces mitotic phase arrest and inhibits G2/M progression significantly which is associated with the upregulation of cyclin B1 and mitotic marker MPM-2 and the dephosphorylation of cdc2. LG308 also induces apoptosis and cell death. LG308 significantly suppresses tumor growth. LG308 with antimitotic activity has the potential for the research of prostate cancer[1].

Name	LG308

Description	LG308 is a novel synthetic compound with antimicrotubule activity. LG308 induces mitotic phase arrest and inhibits G2/M progression significantly which is associated with the upregulation of cyclin B1 and mitotic marker MPM-2 and the dephosphorylation of cdc2. LG308 also induces apoptosis and cell death. LG308 significantly suppresses tumor growth. LG308 with antimitotic activity has the potential for the research of prostate cancer[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
References	[1]. Qin M, et al. LG308, a Novel Synthetic Compound with Antimicrotubule Activity in Prostate Cancer Cells, Exerts Effective Antitumor Activity. J Pharmacol Exp Ther. 2015;355(3):473-483.

Molecular Formula	C₁₉H₁₇FN₂O
Molecular Weight	308.35