2244269-74-5

2244269-74-5 structure

Name: GPR84 antagonist 2
Chemical Name: GPR84 antagonist 2
CAS Number: 2244269-74-5
Molecular Formula: C₂₈H₁₆Cl₂NaO₄PS₂
Molecular Weight: 605.42
Catalog: Signaling Pathways GPCR/G Protein GPR84
Create Date: 2022-04-07 08:42:57
Modify Date: 2024-01-11 23:38:52
GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). GPR84 antagonist 2 shows improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. GPR84 antagonist 2 has the potential for the research of ulcerative colitis[1].

Name	GPR84 antagonist 2

Description	GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). GPR84 antagonist 2 shows improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. GPR84 antagonist 2 has the potential for the research of ulcerative colitis[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> GPR84
References	[1]. Chen LH, et al. Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis. J Med Chem. 2022;65(5):3991-4006.

Molecular Formula	C₂₈H₁₆Cl₂NaO₄PS₂
Molecular Weight	605.42