1185189-97-2
1185189-97-2 structure
- Name: R-PSOP
- Chemical Name: R-PSOP
- CAS Number: 1185189-97-2
- Molecular Formula: C20H22N4O2
- Molecular Weight: 350.41
- Catalog: Research Areas Metabolic Disease
- Create Date: 2022-03-26 22:03:12
- Modify Date: 2025-08-25 11:36:46
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R-PSOP is highly potent and selective nonpeptidic NMUR2 antagonist. R-PSOP binds to NMUR2 with the Kis of 52 and 32 nM for the human and rat NMUR2, respectively. R-PSOP shows moderate CNS penetration. R-PSOP can be used for the research of the eating disorders, obesity, pain, and stress-related disorders[1].
| Name | R-PSOP |
|---|
| Description | R-PSOP is highly potent and selective nonpeptidic NMUR2 antagonist. R-PSOP binds to NMUR2 with the Kis of 52 and 32 nM for the human and rat NMUR2, respectively. R-PSOP shows moderate CNS penetration. R-PSOP can be used for the research of the eating disorders, obesity, pain, and stress-related disorders[1]. |
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| Related Catalog | |
| In Vitro | From Schild analyses, the functional Kb values for R-PSOP are 92 and 155 nM at human and rat NMUR2, respectively (the effects of R-PSOP on the intracellular calcium mobilization response induced by NMU-25 in HEK293 cells expressing human or rat NMUR2)[1]. R-PSOP strongly inhibits the responses stimulated by peptide agonists NMU-25, NMU-23, and NMU-8 in human embryonic kidney 293 cells expressing NMUR2[1]. In functional assays measuring phosphoinositide turnover or intracellular calcium mobilization, R-PSOP strongly inhibits the responses stimulated by peptide agonists NMU-25, NMU-23, and NMU-8 in human embryonic kidney 293 cells expressing NMUR2[1]. R-PSOP concentration-dependently inhibits the phosphoinositide (PI) turnover turnover response in human NMUR2-expressing cells stimulated by 10 nM NMU-25 (EC50 of 5 nM). The IC50 value is determined to be 86 nM[1]. |
| In Vivo | R-PSOP (10 μL 50 nmol; intrathecal injection; male Sprague-Dawley rats) attenuates NMU-23-evoked nociceptive responses in a rat spinal reflex preparation[1]. |
| References |
| Density | 1.35±0.1 g/cm3(Predicted) |
|---|---|
| Boiling Point | 461.7±45.0 °C(Predicted) |
| Molecular Formula | C20H22N4O2 |
| Molecular Weight | 350.41 |
| Storage condition | -20°C |