613263-00-6

613263-00-6 structure

Name: M62812
Chemical Name: M62812
CAS Number: 613263-00-6
Molecular Formula: C₁₃H₁₃Cl₂N₃OS
Molecular Weight: 330.23
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2022-05-18 09:45:39
Modify Date: 2024-04-05 15:59:32
M62812 is a toll-like receptor 4 (TLR4) signaling inhibitor. M62812 inhibits endothelial and leukocyte activation and prevents lethal septic shock in mice. M62812 can reduces LPS-induced coagulation and inflammatory responses. M62812 can be used for the research of sepsis[1].

Name	M62812
Synonyms	6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine dihydrochloride 1,2-Benzisothiazol-3-amine, 6-(2-aminophenoxy)-, hydrochloride (1:2) 6-(2-Aminophenoxy)-1,2-benzothiazol-3-amine dihydrochloride MFCD30179737

Description	M62812 is a toll-like receptor 4 (TLR4) signaling inhibitor. M62812 inhibits endothelial and leukocyte activation and prevents lethal septic shock in mice. M62812 can reduces LPS-induced coagulation and inflammatory responses. M62812 can be used for the research of sepsis[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Infection
References	[1]. Nakamura M, et al. Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur J Pharmacol. 2007 Aug 27;569(3):237-43.