314054-36-9

314054-36-9 structure

Name: HIOC
Chemical Name: HIOC
CAS Number: 314054-36-9
Molecular Formula: C₁₆H₁₉N₃O₃
Molecular Weight: 301.34
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-03-28 19:02:16
Modify Date: 2024-04-11 10:14:58
HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage). HIOC shows protective activity in an animal model for light-induced retinal degeneration[1][2][3].

Name	HIOC
Synonyms	3-Piperidinecarboxamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxo- HIOC N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide

Description	HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage). HIOC shows protective activity in an animal model for light-induced retinal degeneration[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	TrkB ERK
In Vivo	HIOC (C57BL/6 mice, 50 mg/kg, IP, three times per week, for two weeks) increased survival of RGCs (retinal ganglion cells) after ONC (optic nerve crush)[3].
References	[1]. Tang J, et al. Neuroprotective role of an N-acetyl serotonin derivative via activation of tropomyosin-related kinase receptor B after subarachnoid hemorrhage in a rat model. Neurobiol Dis. 2015 Jun;78:126-33. [2]. Noah A.Setterholm, et al.Gram-scale, chemoselective synthesis of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC). Tetrahedron Letters. 3 June 2015;56(23):3413-3415. [3]. Ying Li, et al. Effect of systemic treatment with N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3- carboxamide (HIOC) or tauroursodeoxycholic Acid (TUDCA) on retinal ganglion cell death following optic nerve crush. bioRxiv. 2019 August 14.

Density	1.3±0.1 g/cm3
Boiling Point	746.1±60.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₉N₃O₃
Molecular Weight	301.34
Flash Point	405.0±32.9 °C
Exact Mass	301.142639
LogP	-1.49
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.648

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