2421141-40-2
2421141-40-2 structure
- Name: GLUT inhibitor-1
- Chemical Name: GLUT inhibitor-1
- CAS Number: 2421141-40-2
- Molecular Formula: C32H35N7O2
- Molecular Weight: 549.67
- Catalog: Research Areas Cancer
- Create Date: 2022-03-07 12:43:10
- Modify Date: 2025-08-25 09:33:03
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GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases[1].
| Name | GLUT inhibitor-1 |
|---|
| Description | GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases[1]. |
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| Related Catalog | |
| Target |
GLUT1:242 nM (IC50) GLUT3:179 nM (IC50) |
| In Vivo | Summary of the pharmacokinetic parameters of GLUT inhibitor-1 (compound 15b; 30 mg/kg) in mouse and rat[1]. Parameter Mouse Rat oral Cmax (ng/mL) 2525 1675 oral AUC (ng/mL) 5890 6813 CL (mL/min/kg) 40 37 Vdss (L/Kg) 1.70 4.51 t1/2 (h) 0.785 2.59 F (%) 45.4 49.4 B/Pb 0.05 b: Solubility is determined in PBS buffer solutions. |
| References |
| Molecular Formula | C32H35N7O2 |
|---|---|
| Molecular Weight | 549.67 |