2735803-28-6

2735803-28-6 structure

Name: DS45500853
Chemical Name: DS45500853
CAS Number: 2735803-28-6
Molecular Formula: C₁₈H₂₀O₃
Molecular Weight: 284.35
Catalog: Research Areas Metabolic Disease
Create Date: 2022-03-02 19:57:00
Modify Date: 2024-01-14 12:22:27
DS45500853 is an estrogen-related receptor α (ERRα) agonist. DS45500853 inhibits the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) with an >IC50 value of 0.80 μM. DS45500853 can be used for the research of metabolic disorders, including type 2 diabetes mellitus (T2DM)[1].

Name	DS45500853

Description	DS45500853 is an estrogen-related receptor α (ERRα) agonist. DS45500853 inhibits the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) with an >IC50 value of 0.80 μM. DS45500853 can be used for the research of metabolic disorders, including type 2 diabetes mellitus (T2DM)[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Metabolic Disease
Target	ERRα
References	[1]. Shinozuka T, et al. Discovery of a Novel Class of ERRα Agonists. ACS Med Chem Lett. 2021 Apr 21;12(5):817-821.

Molecular Formula	C₁₈H₂₀O₃
Molecular Weight	284.35