Shanghai Nianxing Industrial Co., Ltd
China
Product Name: DB772
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: DB772
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

1451058-50-6

1451058-50-6 structure

1451058-50-6 structure

Name: DB772
Chemical Name: DB772
CAS Number: 1451058-50-6
Molecular Formula: C₂₀H₁₈Cl₂N₄O
Molecular Weight: 401.29
Catalog: Research Areas Infection
Create Date: 2022-03-07 14:08:28
Modify Date: 2025-09-21 12:56:16
DB772 is a bovine viral diarrhea virus (BVDV, genus Pestivirus, family Flaviviridae) infection inhibitor. Anti-prion activity[1].

Name	DB772

Description	DB772 is a bovine viral diarrhea virus (BVDV, genus Pestivirus, family Flaviviridae) infection inhibitor. Anti-prion activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
In Vitro	DB772 inhibits BVDV in primary sheep microglia and Rov9 cells[2]. DB772 (0.05 μM) is sufficient to completely inhibit HoBi virus replication[2]. DB772 acts as an antiviral agent for use against Hepatitis C virus[2]. DB772 (1 μM) significantly reduces PrPSc-positive spots by 65.8%±5.7%. DB772 (4 μM) results in a nearly complete inhibition of PrPSc accumulation in scrapie-infected primary ovine microglia[3].
References	[1]. James B Stanton, et al. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One. 2012;7(11):e51173. [2]. Benjamin W Newcomer, et al. Efficacy of an antiviral compound to inhibit replication of multiple pestivirus species. Antiviral Res. 2012 Nov;96(2):127-9. [3]. Kelcey D Dinkel, et al. Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5467-82.

Molecular Formula	C₂₀H₁₈Cl₂N₄O
Molecular Weight	401.29

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