2747919-19-1
2747919-19-1 structure
- Name: CDK7/9-IN-1
- Chemical Name: CDK7/9-IN-1
- CAS Number: 2747919-19-1
- Molecular Formula: C24H32F3N5O2
- Molecular Weight: 479.54
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2022-03-05 18:03:11
- Modify Date: 2024-02-04 17:41:58
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CDK7/9-IN-1 is a cyclin-dependent kinases 7/9 (CDK7/9) inhibitor. CDK7/9-IN-1 selectively inhibits CDK7 over CDK9. CDK7/9-IN-1 inhibits CDK7 with IC50s of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. CDK7/9-IN-1 can be used for the research of cancer[1].
| Name | CDK7/9-IN-1 |
|---|
| Description | CDK7/9-IN-1 is a cyclin-dependent kinases 7/9 (CDK7/9) inhibitor. CDK7/9-IN-1 selectively inhibits CDK7 over CDK9. CDK7/9-IN-1 inhibits CDK7 with IC50s of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. CDK7/9-IN-1 can be used for the research of cancer[1]. |
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| Related Catalog | |
| Target |
CDK7:5.74-65.6 nM (IC50) CDK9:2.14 μM (IC50) |
| In Vitro | CDK7/9-IN-1 (example 8; 0.001-20 μM; 4 h) inhibits CDK7 with an relative IC50 of 0.0262 μM for phospho-carboxyl terminal domain (Rbp2) (Ser5) in HCT116 cells[1]. CDK7/9-IN-1 (0.001-20 μM; 4 h) inhibits CDK9 with an IC50 of 2.59 μM for phospho-carboxyl terminal domain (Rbp2) (Ser2) in HCT116 cells[1]. CDK7/9-IN-1 (0.001-20 μM; 4 h) inhibits cMyc with an relative IC50 of 0.0138 μM in HCT116 cells[1]. CDK7/9-IN-1 (20 μΜ, 2 μΜ, and 0.2 μΜ; 1 h) shows excellent selectivity against the 468 protein kinases panel. CDK7/9-IN-1 shows approximately 96% inhibition against CDK7[1]. |
| References |
[1]. Maria Carmen FERNANDEZ FIGUEROA, et al. Compounds useful for inhibiting cdk7. WO2021242602 A1. |
| Molecular Formula | C24H32F3N5O2 |
|---|---|
| Molecular Weight | 479.54 |