Shanghai Nianxing Industrial Co., Ltd
China
Product Name: LAS191859
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Purity: 98.0%
Stocking Period: 10 Day
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1420071-13-1

1420071-13-1 structure

1420071-13-1 structure

Name: las191859
Chemical Name: las191859
CAS Number: 1420071-13-1
Molecular Formula: C₂₄H₂₄F₃N₃O₃
Molecular Weight: 459.46
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2022-02-04 11:24:11
Modify Date: 2024-04-08 09:12:02
LAS191859 is an orally active, potent and selective CRTh2 antagonist with an IC50 of 9.58 nM against human CRTh2. LAS191859 can be used for the research of chronic asthma[1].

Name	las191859

Description	LAS191859 is an orally active, potent and selective CRTh2 antagonist with an IC50 of 9.58 nM against human CRTh2. LAS191859 can be used for the research of chronic asthma[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Inflammation/Immunology
Target	IC50: 7.6 nM (guinea pig CRTh2), 9.58 nM (human CRTh2), 14 nM (rat CRTh2), 15.5 nM (mouse CRTh2)[1]
References	[1]. Calbet M, et al. Pharmacological characterization of CRTh2 antagonist LAS191859: Long receptor residence time translates into long-lasting in vivo efficacy. Pharmacol Res. 2016 Sep;111:208-216.

Molecular Formula	C₂₄H₂₄F₃N₃O₃
Molecular Weight	459.46

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