264275-77-6
264275-77-6 structure
- Name: XVA143
- Chemical Name: XVA143
- CAS Number: 264275-77-6
- Molecular Formula: C25H21Cl2N3O8
- Molecular Weight: 562.36
- Catalog: Signaling Pathways Cytoskeleton Integrin
- Create Date: 2021-12-19 09:09:43
- Modify Date: 2024-01-21 07:14:27
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XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo[1].
| Name | XVA143 |
|---|
| Description | XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo[1]. |
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| Related Catalog | |
| In Vitro | XVA143 (1 μM) completely abolishes binding of ICAM-1 to LFA-1 in Mn2+ and Mg2+/EGTA, with no hint of agonism[1].XVA143 restores rolling of the αL-E310A β2 mutant by inducing extension of αL[2]. Cell Viability Assay[1] Cell Line: K562 cells. Concentration: 0, 0.2, 0.5 and 1 μM. Incubation Time: Result: Potent against the weakest activator (2 mM Mg2+/1 mM EGTA, IC50 ~10-3 nM) and least potent against the strongest activator (1 mM Mn2+, IC50 ~10-3 nM). Cell Viability Assay[1] Cell Line: Wild-type murine lymphocytes[1]. Concentration: 100 μM. Incubation Time: Result: Induced a 50% increase in rolling fraction compared to vehicle-treated control cells ((from 27±5% to 41±7%). |
| References |
| Molecular Formula | C25H21Cl2N3O8 |
|---|---|
| Molecular Weight | 562.36 |