2167246-24-2
2167246-24-2 structure
- Name: Rimtuzalcap
- Chemical Name: Rimtuzalcap
- CAS Number: 2167246-24-2
- Molecular Formula: C18H24F2N6O
- Molecular Weight: 378.42
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2022-01-20 07:02:35
- Modify Date: 2024-03-06 13:43:56
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Rimtuzalcap (CAD-1883) is a first-in-class selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels). Rimtuzalcap can be used for the research of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA)[1].
| Name | Rimtuzalcap |
|---|
| Description | Rimtuzalcap (CAD-1883) is a first-in-class selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels). Rimtuzalcap can be used for the research of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA)[1]. |
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| Related Catalog | |
| In Vitro | Rimtuzalcap (Compound 1) is a small molecule modulator of potassium ion channels showing great therapeutic potential for treating a variety of diseases characterized by dysfunction of potassium ion channels and dysfunction from other causes which influence these potassium channels[1]. |
| In Vivo | Rimtuzalcap (CAD-1883) reduces the firing rate of Purkinje cells by approximately 40%, consistent with the anticipated therapeutic mechanism of positive allosteric modulation of SK channels. Sequential bath application of 1 or 3 µM CAD-1883 results in a partial reversal of the increased coefficient of variation of the interspike interval which is seen in cerebellar slices from 11-month-old spinocerebellar ataxia-2 58Q mice[1]. |
| References |
[1]. Crystalline forms of potassium channel modulators. WO2020086456A1. |
| Molecular Formula | C18H24F2N6O |
|---|---|
| Molecular Weight | 378.42 |