2129993-56-0

2129993-56-0 structure

Name: Fostroxacitabine bralpamide
Chemical Name: Fostroxacitabine bralpamide
CAS Number: 2129993-56-0
Molecular Formula: C₂₂H₃₀BrN₄O₈P
Molecular Weight: 589.37
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2022-01-31 21:14:06
Modify Date: 2024-01-12 11:33:09
Fostroxacitabine bralpamide (MIV-818) is an orally active Troxacitabine-based nucleotide prodrug. Fostroxacitabine bralpamide has anticancer effects[1].

Name	Fostroxacitabine bralpamide

Description	Fostroxacitabine bralpamide (MIV-818) is an orally active Troxacitabine-based nucleotide prodrug. Fostroxacitabine bralpamide has anticancer effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
In Vitro	Fostroxacitabine bralpamide (MIV-818) is highly metabolized by human hepatocytes, directing high levels of the chain-terminating nucleotide tri-phosphate to the liver. The tri-phosphate is incorporated into DNA during replication, which leads to DNA double strand breaks, DNA damage responses, and cytotoxicity[1].
References	[1]. T.R. Jeffry Evans, et al. Phase I study of the novel pro-drug MIV-818 in patients with hepatocellular carcinoma, intra-hepatic cholangiocarcinoma or liver metastases.

Molecular Formula	C₂₂H₃₀BrN₄O₈P
Molecular Weight	589.37