2238831-60-0
2238831-60-0 structure
- Name: Datopotamab deruxtecan
- Chemical Name: Datopotamab deruxtecan
- CAS Number: 2238831-60-0
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
- Create Date: 2021-12-19 16:44:58
- Modify Date: 2024-01-04 19:22:24
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Datopotamab deruxtecan (DS-1062; Dato-DXd) is a trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC). Datopotamab deruxtecan has a potent antitumor activity[1].
| Name | Datopotamab deruxtecan |
|---|
| Description | Datopotamab deruxtecan (DS-1062; Dato-DXd) is a trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC). Datopotamab deruxtecan has a potent antitumor activity[1]. |
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| Related Catalog | |
| Target |
Topoisomerase I |
| In Vitro | Datopotamab deruxtecan (Dato-DXd; 100 μg/mL) binds specifically to TROP2 and was internalized into tumor cells followed by intracellular trafficking to lysosome and Deruxtecan release, which induced DNA damage and apoptosis in TROP2-expressing tumor cells in vitro[1]. |
| In Vivo | Datopotamab deruxtecan (Dato-DXd; 6 mg/kg) shows potent antitumor activity with tumor regression in several TROP2-expressing xenograft tumors including NSCLC patient-derived xenograft (PDX) models. Safety profiles of Datopotamab deruxtecan in rats and cynomolgus monkeys are acceptable[1]. |
| References |
| No Any Chemical & Physical Properties |