2143917-62-6
2143917-62-6 structure
- Name: Cirtuvivint
- Chemical Name: Cirtuvivint
- CAS Number: 2143917-62-6
- Molecular Formula: C24H25N7O
- Molecular Weight: 427.50
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2021-12-27 13:10:56
- Modify Date: 2024-01-12 09:56:02
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Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor. Cirtuvivint can be used for solid tumors research[1].
| Name | Cirtuvivint |
|---|
| Description | Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor. Cirtuvivint can be used for solid tumors research[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Cirtuvivint (SM08502) inhibits serine and arginine rich splicing factor (SRSF) phosphorylation and disrupted spliceosome activity, which is associated with inhibition of Wnt pathway-related gene and protein expression. Cirtuvivint induces the generation of splicing variants of Wnt pathway genes, suggesting that its mechanism for inhibition of gene expression includes effects on alternative splicing[1]. |
| In Vivo | Orally administered Cirtuvivint (SM08502) significantly inhibits growth of gastrointestinal tumors and decreased SRSF phosphorylation and Wnt pathway gene expression in xenograft mouse models[1]. |
| References |
| Molecular Formula | C24H25N7O |
|---|---|
| Molecular Weight | 427.50 |