2064121-65-7

2064121-65-7 structure

Name: Asundexian
Chemical Name: Asundexian
CAS Number: 2064121-65-7
Molecular Formula: C₂₆H₂₁ClF₄N₆O₄
Molecular Weight: 592.93
Catalog: Signaling Pathways Metabolic Enzyme/Protease Factor Xa
Create Date: 2021-12-19 10:41:45
Modify Date: 2024-01-02 19:38:01
Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM[1].

Name	Asundexian

Description	Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa
In Vivo	Asundexian displays potent anticoagulant activity in vitro in human and rabbit plasma and antithrombotic efficacy in vivo in a rabbit arterial thrombosis model[1].
References	[1]. Thomas D, et al. First evaluation of the safety, pharmacokinetics, and pharmacodynamics of BAY 2433334, a small molecule targeting coagulation factor XIa. J Thromb Haemost. 2021;19(10):2407-2416.

Molecular Formula	C₂₆H₂₁ClF₄N₆O₄
Molecular Weight	592.93