384376-42-5

384376-42-5 structure

Name: D75-4590
Chemical Name: D75-4590
CAS Number: 384376-42-5
Molecular Formula: C₂₁H₂₇N₅
Molecular Weight: 349.47
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2022-01-12 19:23:56
Modify Date: 2025-08-20 13:02:29
D75-4590, a pyridobenzimidazole derivative and a β-1,6-glucan synthesis inhibitor, possesses antifungal activity[1].

Name	D75-4590
Synonyms	1-{[2-(Diethylamino)ethyl]amino}-2-ethyl-3-methylpyrido[1,2-a]benzimidazole-4-carbonitrile D75-4590 MFCD05738885 Pyrido[1,2-a]benzimidazole-4-carbonitrile, 1-[[2-(diethylamino)ethyl]amino]-2-ethyl-3-methyl-

Description	D75-4590, a pyridobenzimidazole derivative and a β-1,6-glucan synthesis inhibitor, possesses antifungal activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Inflammation/Immunology
In Vitro	D75-4590 has activities against a variety of Candida species, including fluconazole-resistant strains. Most strains of C. albicans, C. tropicalis, and C. parapsilosis displayed trailing growth phenomena similar to those observed in the presence of azoles[1].
References	[1]. Akihiro Kitamura, et al. Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis. Antimicrob Agents Chemother. 2009 Feb;53(2):670-7.