1404437-49-5

1404437-49-5 structure

Name: STK33-IN-1
Chemical Name: N-[3-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-1-(4-methoxyphenyl)-6-pyrazolo[3,4-d]pyrimidinamine
CAS Number: 1404437-49-5
Molecular Formula: C₂₄H₂₇N₇O₂
Molecular Weight: 445.52
Catalog: Research Areas Cancer
Create Date: 2022-01-14 18:27:52
Modify Date: 2024-01-29 20:00:57
STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC50 of 7 nM[1].

Name	N-[3-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-1-(4-methoxyphenyl)-6-pyrazolo[3,4-d]pyrimidinamine
Synonyms	N-[3-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-1-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine N-[3-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-1-(4-methoxyphenyl)-6-pyrazolo[3,4-d]pyrimidinamine 1H-Pyrazolo[3,4-d]pyrimidin-6-amine, N-[3-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-1-(4-methoxyphenyl)-

Description	STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC50 of 7 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 7 nM (STK33)[1].
In Vitro	STK33-IN-1 (compound 1) is 2-fold selective for Aurora-B (AurB) versus STK33. STK33-IN-1 (compound 1) has proven unsuccessful in selectively killing KRAS-dependent cancer cell lines[1].
References	[1]. Michel Weïwer, et al. A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038.