1070881-42-3

1070881-42-3 structure

Name: Terevalefim
Chemical Name: 3-[(E)-2-(2-Thienyl)vinyl]pyrazolidine
CAS Number: 1070881-42-3
Molecular Formula: C₉H₈N₂S
Molecular Weight: 176.24
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Met/HGFR
Create Date: 2022-03-04 11:12:11
Modify Date: 2024-01-14 08:29:04
Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor[1][2].

Name	3-[(E)-2-(2-Thienyl)vinyl]pyrazolidine
Synonyms	Pyrazolidine, 3-[(E)-2-(2-thienyl)ethenyl]- 3-[(E)-2-(2-Thienyl)vinyl]pyrazolidine

Description	Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
In Vitro	Terevalefim (ANG-3777) (0-10 μM) significantly inhibited cancer cells proliferation in HUVECs[2]. Cell Viability Assay[2] Cell Line: Human Umbilical Vein Epithelial Cells (HUVECs). Concentration: 0.44, 1.78, and 7.1 μM. Incubation Time: 24 to 48 hours. Result: Dose-dependently inhibited cell proliferation.
In Vivo	Terevalefim (ANG-3777) decreases apoptosis, increases proliferation, and promotes organ repair and function in animal models[1]. Terevalefim (ANG-3777, 40 mg/kg, IP) phosphorylates the c-Met receptor in rats[2]. Animal Model: SD rats[2]. Dosage: 40 mg/kg. Administration: IP injection, once. Result: Selectively phosphorylated the c-Met receptor and not other growth factor receptors.
References	[1]. Jonathan S Bromberg, et al. Renal Function Improvement Following ANG-3777 Treatment in Patients at High Risk for Delayed Graft Function After Kidney Transplantation. Transplantation. 2021 Feb 1;105(2):443-450. [2]. Latha Paka, et al. The Effect of ANG-3777 on Hepatocyte Growth Factor Receptor, c-MET Signaling. American Transplant Society.