2387821-46-5
2387821-46-5 structure
- Name: HB007
- Chemical Name: HB007
- CAS Number: 2387821-46-5
- Molecular Formula: C15H9ClN4Os
- Molecular Weight: 328.78
- Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
- Create Date: 2021-11-01 14:23:17
- Modify Date: 2024-04-12 19:18:11
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HB007 is a small ubiquitin-related modifier 1 (SUMO1) degrader. HB007 induces ubiquitination and degradation of SUMO1, resulting in reduced tumor growth in vivo. HB007 can be used for the research of brain, breast, colon, and lung cancers[1][2].
| Name | HB007 |
|---|
| Description | HB007 is a small ubiquitin-related modifier 1 (SUMO1) degrader. HB007 induces ubiquitination and degradation of SUMO1, resulting in reduced tumor growth in vivo. HB007 can be used for the research of brain, breast, colon, and lung cancers[1][2]. |
|---|---|
| Related Catalog | |
| Target |
SUMO1[1] |
| In Vitro | HB007 (compound 24) (0.1-100 μM) inhibits LN229 cell growth in a concentration-dependent manner t[1]. HB007 (10-25 μM) reduces SUM01 conjugation and total protein levels of SUM01 but not SUM02/3 or UB in LN229 cells t[1]. |
| In Vivo | HB007 (compound 24) (25-50 mg/kg; i.p. for 15 d) significantly suppresses tumor growth of colon and lung cancer but had no effect on the body weights of mice[1]. |
| References |
[2]. BELLAIL A, et, al. Compositions and methods for treating cancer. WO2019217509A1. |
| Molecular Formula | C15H9ClN4Os |
|---|---|
| Molecular Weight | 328.78 |